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Testing 255 combinations of chemicals versus bacterial communities shows species diversity contributes to resilience against increasingly complex stressor mixtures.
Deep investigation of the sequence-structure-function landscape of the tetracycline destructase family of antibiotic resistance enzymes identifies new enzymes, and amino acid spositions essential to activity.
In this study, Liu et al. explore the interplay between a fungal effector and a plant cysteine protease and design a small-molecule compound aimed at targeting this effector to combat rice blast disease.
Known as tethered macrocyclic peptides, a new class of antibiotics show potent activity against drug-resistant strains of Acinetobacter baumannii — with one candidate already in clinical trials.
In vitro models mimicking in-patient conditions have the potential to yield exciting opportunities for antibiotic research and revitalize future antibiotic discovery and development.