Antimicrobial responses

Antimicrobial responses refer to any host process triggered by the exposure to a microorganism that results in a change in state, activity or viability of the microorganism – for example, movement, secretion, enzyme production or gene expression.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    A new study in Science identifies nemuri (nur) as encoding a secreted factor in Drosophila that has both antimicrobial and sleep-inducing properties, thus providing a direct link between sleep homeostasis and the response to infection.

    • Kirsty Minton
  • News and Views |

    The discovery of CD153 as a novel driver of T-cell-mediated host defence against Mycobacterium tuberculosis infection advances our understanding of the requirements for protective immunity. Future investigation of CD153 as a potential correlate of tuberculosis immunity could open new avenues for vaccine design.

    • Sara B. Cohen
    •  & Kevin B. Urdahl
    Nature Microbiology 3, 1194-1195
  • News and Views |

    The H445Y mutation in the β-subunit of RNA polymerase in Mycobacterium tuberculosis causes resistance to the antibiotic rifampicin and changes mycobacterial lipid composition. Infection with rpoB H445Y results in metabolic shifts that allow the bacteria to bypass a key host inflammatory response.

    • Yu-Xiang Chen
    •  & Babak Javid
    Nature Microbiology 3, 1078-1079