Antibiotics articles from across Nature Portfolio

Antibiotics are substances that inhibit the growth of bacteria. They work by killing bacteria or preventing their reproduction, and may be synthesized chemically or by naturally-occurring or engineered organisms.

Latest Research and Reviews

Research | 03 June 2023

Distinct bacterial population dynamics and disease dissemination after biofilm dispersal and disassembly
- Yeping Ma
- , Yanlin Deng
- & Song Lin Chua
The ISME Journal, 1-13
Research | 01 June 2023

Avidumicin, a novel cyclic bacteriocin, produced by Cutibacterium avidum shows anti-Cutibacterium acnes activity
- Juri Koizumi
- , Keisuke Nakase
- & Hidemasa Nakaminami
The Journal of Antibiotics, 1-11
Research
31 May 2023 | Open Access

Reduced selection for antibiotic resistance in community context is maintained despite pressure by additional antibiotics
- Peiju Fang
- , Alan Xavier Elena
- & Uli Klümper
ISME Communications 3, 52
Research | 19 May 2023

Dactylides A−C, three new bioactive 22-membered macrolides produced by Dactylosporangium aurantiacum
- Pankaj Kumar
- , Yedukondalu Nalli
- & Pramod B. Shinde
The Journal of Antibiotics, 1-8
Reviews | 19 May 2023

Translating eco-evolutionary biology into therapy to tackle antibiotic resistance

In this Review, Martínez, Hernando-Amado and colleagues explore how eco-evolutionary-based approaches can aid in the design of successful antibiotic therapies, including the exploitation of evolutionary trade-offs, targeting bacterial metabolism and studying the ancestral functions of antibiotic resistance determinants.
- Fernando Sanz-García
- , Teresa Gil-Gil
- & Sara Hernando-Amado
Nature Reviews Microbiology, 1-15
Reviews
10 May 2023 | Open Access

Intradiscal pharmacokinetics of oral antibiotics to treat Chronic Lower Back Pain
- Lloyd G. Czaplewski
- , Marcus Zeitlinger
- & Joseph F. Standing
npj Antimicrobials and Resistance 1, 1

All Research & Reviews

News and Comment

Research Highlights | 12 May 2023

Reviving colistin

In this study, Carfrae et al. show that inhibition of biotin and fatty acid synthesis restores colistin activity against Gram-negative bacteria and prevents colistin resistance.
- Agustina Taglialegna
Nature Reviews Microbiology, 1
News & Views | 01 May 2023

Inhibitors of fatty acid synthesis counter resistance to last-resort antibiotic colistin

Colistin-resistant bacteria require fatty acid synthesis to maintain cell envelope homeostasis; disrupting fatty acid biosynthesis leads to the remodelling of phospholipid composition and decreases the fluidity of the cell envelope. Inhibitors of fatty acid biosynthesis resensitize bacteria to colistin, allowing for the treatment of colistin-resistant bacterial infections in mice.

Nature Microbiology 8, 1006-1007
News & Views | 26 April 2023

Step-by-step assembly of a β-barrel protein in a bacterial membrane

Gram-negative bacteria that are resistant to multiple drugs cannot survive without the cell-surface machinery that builds a β-barrel pore structure from outer membrane proteins. Snapshots of different stages in the assembly process provide insights into this crucial mechanism, and could lead to the development of new antibiotics.

Nature
Research Highlights | 22 March 2023

Heat up the antibiotics

This study reports that heat treatment can increase the bactericidal activity of aminoglycosides against multi-drug resistant pathogens.
- Agustina Taglialegna
Nature Reviews Microbiology 21, 277
News | 27 February 2023

One MRI for 4.7 million people: the battle to treat Syria’s earthquake survivors

With only 64 X-ray and 73 kidney-dialysis machines, 7 CT scanners and one MRI machine, doctors in northwest Syria are racing against the clock to treat 8,500 injuries.
- Miryam Naddaf
Nature 615, 193-194
Research Highlights | 23 February 2023

One dose of antibiotic reduces sepsis in childbirth

A single dose of azithromycin substantially reduced maternal sepsis and death, according to a large, international, randomized study.
- Karen O’Leary
Nature Medicine

All News & Comment

Antibiotics articles from across Nature Portfolio

Latest Research and Reviews

Distinct bacterial population dynamics and disease dissemination after biofilm dispersal and disassembly

Avidumicin, a novel cyclic bacteriocin, produced by Cutibacterium avidum shows anti-Cutibacterium acnes activity

Reduced selection for antibiotic resistance in community context is maintained despite pressure by additional antibiotics

Dactylides A−C, three new bioactive 22-membered macrolides produced by Dactylosporangium aurantiacum

Translating eco-evolutionary biology into therapy to tackle antibiotic resistance

Intradiscal pharmacokinetics of oral antibiotics to treat Chronic Lower Back Pain

News and Comment

Reviving colistin

Inhibitors of fatty acid synthesis counter resistance to last-resort antibiotic colistin

Step-by-step assembly of a β-barrel protein in a bacterial membrane

Heat up the antibiotics

One MRI for 4.7 million people: the battle to treat Syria’s earthquake survivors

One dose of antibiotic reduces sepsis in childbirth

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