Analytical biochemistry articles within Nature Communications

Featured

• Article | 19 November 2014

  Active accumulation of very diluted biomolecules by nano-dispensing for easy detection below the femtomolar range

  Biomolecule detection is important in many fields, but obviously becomes increasingly difficult as concentrations decrease. Here, the authors demonstrate a method to dispense and concentrate biomolecules onto a target slide, greatly improving the detection limits.

  • S. Grilli
  • , L. Miccio
  •  & P. Ferraro

• Article | 17 March 2014

  One-step pipetting and assembly of encoded chemical-laden microparticles for high-throughput multiplexed bioassays

  High-throughput screening allows for the rapid assessment of biochemical compounds and processes, but with increasing scale comes increasing costs. Here, the authors use an array of lithographically encoded hydrogel microparticles as a more accessible screening technique.

  • Su Eun Chung
  • , Jiyun Kim
  •  & Sunghoon Kwon

• Article
  18 December 2012 | Open Access

  Multiplexed volumetric bar-chart chip for point-of-care diagnostics

  Diagnostic microfluidic devices often require complicated optical systems and computers to quantify results. Here, Qin and colleagues link enzymatic biomarker detection with the displacement of ink, resulting in a device that displays quantitative results as bar graphs directly on the device.

  • Yujun Song
  • , Yuanqing Zhang
  •  & Lidong Qin

• Article
  16 November 2010 | Open Access

  Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase

  The influenza virus life cycle relies on sialidases, which are classified as group-1 or group-2, depending on the flexibility of the '150-loop'. In this study, chemical compounds are developed, which lock open the '150-loop', selectively inhibiting the activity of group-1 sialidases.

  • Santosh Rudrawar
  • , Jeffrey C. Dyason
  •  & Mark von Itzstein