Adult neurogenesis articles from across Nature Portfolio

Xu et al. use single-cell transcriptomics to reveal that targeted and systemic partial reprogramming restore the production of neuronal progenitors and new neurons in old mice and show a cell-autonomous effect of reprogramming in cultures of aged neural stem cells.

The molecular mechanisms controlling injury-dependent neuronal regeneration are largely unknown. Here, the authors use integrated multiomic analysis to characterize gene regulatory networks controlling injury-induced neurogenesis in zebrafish retina

The functions of newborn cells arising from the subventricular zone in response to stroke have been unclear. Here, the authors show that cells migrating from the subventricular zone after stroke promote brain repair and functional recovery in mice.

In mice, specific pools of adult neural stem cells are recruited during pregnancy to support postpartum maternal behaviour.

In this Journal Club, María Llorens-Martín describes a 1983 paper that revealed ongoing neurogenesis in the brains of adult female canaries.

The extent to which neurogenesis occurs in adult primates is still controversial. Single-cell RNA sequencing, immunofluorescence staining, and ex vivo neurosphere culture experiments were performed using the adult macaque hippocampus. The results reveal robust adult neurogenesis in the dentate gyrus of the primate hippocampus.

Neuronal activity in a key region of the mouse hypothalamus modulates adult hippocampal neurogenesis, promoting the formation of adult-born neurons that support cognition and affective function.

Bone marrow transplantation causes peripheral cells to engraft the brain by an unclear mechanism. Microglia, the brain’s immune cells, lose their regenerative capacity when the bone marrow transplantation chemotherapy agent busulfan arrests their cell cycle. This causes a gradual decrease in microglial density, creating a niche for peripheral donor cells to engraft the brain and become resident macrophages.