Acute kidney injury

Acute kidney injury (AKI) is a rapid deterioration in kidney function that occurs within 48 hours of an initiating event and is associated with an absolute increase in serum creatinine of ≥26.4 μmol/l. Main causes of AKI include sepsis, ischaemia-reperfusion injury and nephrotoxins. Symptoms include fatigue, loss of appetite, headache, nausea and vomiting.

Latest Research and Reviews

Research
02 August 2022 | Open Access

Serum myo-inositol oxygenase levels at hospital discharge predict progression to chronic kidney disease in community-acquired acute kidney injury
- Tom Jose Kakkanattu
- , Jaskiran Kaur
- & Vivekanand Jha
Scientific Reports 12, 13225
Research
27 June 2022 | Open Access

Acute kidney injury secondary to urinary tract infection in kidney transplant recipients
- Tomasz Królicki
- , Klaudia Bardowska
- & Dorota Kamińska
Scientific Reports 12, 10858
Reviews | 22 June 2022

Role of the cGAS–STING pathway in systemic and organ-specific diseases

The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway not only is involved in host defence against infection but can lead to immune dysregulation. Here, the authors examine the biology and biochemistry of cGAS–STING and discuss its role in disease and potential approaches to therapeutic targeting.
- Sladjana Skopelja-Gardner
- , Jie An
- & Keith B. Elkon
Nature Reviews Nephrology, 1-15
Research
22 June 2022 | Open Access

LncRNA IRAR regulates chemokines production in tubular epithelial cells thus promoting kidney ischemia-reperfusion injury
- Ping Jia
- , Sujuan Xu
- & Xiaoqiang Ding
Cell Death & Disease 13, 562
Research | 08 June 2022

Documentation of acute kidney injury at discharge from the neonatal intensive care unit and role of nephrology consultation
- Jennifer Chmielewski
- , Paulomi M. Chaudhry
- & Shanthy Sridhar
Journal of Perinatology 42, 930-936
Reviews | 31 May 2022

Extracellular vesicles in kidney disease

In this Review, the authors discuss the roles of extracellular vesicles in kidney physiology and disease as well as the beneficial effects of stem cell-derived extracellular vesicles in preclinical models of acute kidney injury and chronic kidney disease. They also highlight current and future clinical applications of extracellular vesicles in kidney diseases.
- Cristina Grange
- & Benedetta Bussolati
Nature Reviews Nephrology 18, 499-513