Acute kidney injury affects one in five hospitalized patients and can lead to lasting kidney damage or death. We show that clonal hematopoiesis of indeterminate potential — a common age-related condition caused by blood cell mutations — increases the risk of acute kidney injury in multiple cohorts of human patients and in mouse models.
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References
Bhatraju, P. K. et al. Association between early recovery of kidney function after acute kidney injury and long-term clinical outcomes. JAMA Netw. Open 3, e202682–e202682 (2020). This paper reports on longitudinal outcomes of the ASSESS-AKI study, which followed patients with AKI for up to 5 years.
Jaiswal, S. et al. Age-related clonal hematopoiesis associated with adverse out-comes. N. Engl. J. Med. 371, 2488–2498 (2014). This paper reports an association among CHIP, cardiovascular disease and mortality.
Vlasschaert, C. et al. Association of clonal hematopoiesis of indeterminate potential with worse kidney function and anemia in two cohorts of patients with advanced chronic kidney disease. J. Am. Soc. Nephrol. 33, 985–995 (2022). This paper reports an association between CHIP and a decline in kidney function among people with chronic kidney disease.
Kestenbaum, B. et al. Clonal hematopoiesis of indeterminate potential and kidney function decline in the general population. Am. J. Kidney Dis. 81, 329–335 (2023). This paper reports an association between CHIP and a decline in kidney function in the general population.
Vlasschaert, C., Lanktree, M. B., Rauh, M. J., Kelly, T. N. & Natarajan, P. Clonal haematopoiesis, ageing and kidney disease. Nat. Rev. Nephrol. 20, 161–174 (2023). This review article highlights the direct and indirect effects of CHIP on kidney health, including its effects on renal function, cardiovascular disease and metabolic diseases that affect the kidney, such as diabetes and obesity.
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This is a summary of: Vlasschaert, C. et al. Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury. Nat. Med. https://doi.org/10.1038/s41591-024-02854-6 (2024).
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Acquired blood mutations cause acute kidney injury via dysregulated inflammation. Nat Med 30, 646–647 (2024). https://doi.org/10.1038/s41591-024-02861-7
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DOI: https://doi.org/10.1038/s41591-024-02861-7
