Acetylation

Acetylation is any chemical reaction that adds an acetyl chemical group (CH3C=O, sometimes abbreviated in chemical structures as Ac) and is a type of acylation reaction. Acetylation of proteins, generally on lysine residues, via an acetyl-coenzyme A donor, can have functional consequences, as in proteins contained within chromatin and metabolic enzymes.

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News and Comment

  • News & Views |

    Sirtuins are highly conserved enzymes with key roles in life extension in multiple organisms. A study now describes selective autophagic degradation of nuclear SIRT1 in senescent cells. These observations suggest that blocking sirtuin degradation could be a potential approach for anti-ageing therapies.

    • Jay X. Tan
    •  & Toren Finkel
    Nature Cell Biology 22, 1159-1161
  • News & Views |

    PD-L1 has been extensively described as the membrane-bound ligand of PD-1. A recent study discovered a previously unknown role for PD-L1, which is able to bind DNA and thus govern different pathways linked to either evasion of immune surveillance or tumour microenvironment inflammation.

    • Alison Jaccard
    •  & Ping-Chih Ho
    Nature Cell Biology 22, 1031-1032
  • News & Views |

    The non-specific lethal (NSL) complex is a highly conserved MOF acetyltransferase-containing complex. A recent study now shows that the NSL complex acetylates a new non-histone target, Lamin A/C and reveals the NSL complex as a crucial factor in maintaining nuclear architecture and genome integrity.

    • Varvara V. Popova
    •  & Jerry L. Workman
    Nature Cell Biology 21, 1177-1178