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A novel spray-type dextrin hydrogel-based adhesion barrier is composed of N-hydroxysuccinimide-modified carboxymethyl dextrin that is biodegradable polymer material. The performance evaluation of a spray-type adhesion barrier in porcine laparoscopic model was showed significantly lowered adhesion rate than in the control group (p < 0.001), and no hydrogel residue was observed macroscopically at the spraying site 28 ± 1 days after surgery.