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Development of a spray-type adhesion barrier

Polymer Journal volume 52, pages 473–479 (2020)Cite this article

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Abstract

We developed a novel spray-type dextrin hydrogel-based adhesion barrier designed to create a site-specific barrier on a target. Our novel hydrogel is composed of Powder A, which mainly contains N-hydroxysuccinimide-modified carboxymethyl dextrin and trehalose as a stabilizing agent, and Powder B, which is composed of sodium carbonate and sodium hydrogen carbonate. Here, we describe the product specifications of the hydrogel and results of in vivo performance evaluations and clinical studies to demonstrate its efficacy and safety.

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Acknowledgements

The authors would like to express their sincere gratitude to all those who collaborated and supported this research and for “The Award of the Society of Polymer Science, Japan (Technology) 2017” awarded by the Society of Polymer Science, Japan, for this study, “Development of a spray-type adhesion barrier”.

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Authors and Affiliations

  1. Terumo Corporation, R&D Center, 1500 Inokuchi Nakai-machi, Ashigarakami-gun, Kanagawa, Japan

    Naotaka Chino, Hiroyuki Ishihara, Taishi Niimi, Miho Kai & Tetsuro Kawanishi

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  1. Naotaka Chino
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  2. Hiroyuki Ishihara
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  3. Taishi Niimi
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  4. Miho Kai
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  5. Tetsuro Kawanishi
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Correspondence to Naotaka Chino.

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Chino, N., Ishihara, H., Niimi, T. et al. Development of a spray-type adhesion barrier. Polym J 52, 473–479 (2020). https://doi.org/10.1038/s41428-020-0306-0

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