No. 5 May 2023Anterograde intraflagellar transport trains
Using a combination of cryo-electron tomography and structure prediction approaches, Lacey et al. reveal the molecular structure of IFT-A and IFT-B trains, providing insights into anterograde transport of cargo into the cilia tip.
See Lacey et al.
No. 4 April 2023Adipokine leptin-induced receptor assembly
Structural studies reveal how adipokine leptin induces trimerization of the leptin receptor in the hypothalamus to convey cellular signaling through the resulting cytokine–receptor assembly.
See Tsirigotaki et al.
No. 3 March 2023PRPS1 assembles for allosteric activation
A series of cryo-EM structures elucidate the function of PRPS1 filament formation from D3 symmetric hexamers, which stabilizes allosteric sites within the enzyme and promotes its activation.
See Hvorecny et al.
No. 2 February 2023Regulation of Cas7-11 by TPR-CHAT
The CRISPR-guided nuclease Cas7-11 forms a bird-like Craspase complex with the regulatory protease TPR-CHAT.
See Ekundayo et al.
No. 1 January 2023A single rRNA modification gates ribosome assembly
A single 2′-O-methylation of ribosomal RNA gates the assembly of a functional ribosome.
See Yelland et al.