Using a combination of cryo-electron tomography and structure prediction approaches, Lacey et al. reveal the molecular structure of IFT-A and IFT-B trains, providing insights into anterograde transport of cargo into the cilia tip.

See Lacey et al.

Structural studies reveal how adipokine leptin induces trimerization of the leptin receptor in the hypothalamus to convey cellular signaling through the resulting cytokine–receptor assembly.

See Tsirigotaki et al.

A series of cryo-EM structures elucidate the function of PRPS1 filament formation from D3 symmetric hexamers, which stabilizes allosteric sites within the enzyme and promotes its activation.

See Hvorecny et al.

The CRISPR-guided nuclease Cas7-11 forms a bird-like Craspase complex with the regulatory protease TPR-CHAT.

See Ekundayo et al.

A single 2′-O-methylation of ribosomal RNA gates the assembly of a functional ribosome.

See Yelland et al.