Volume 30

  • No. 5 May 2023

    Anterograde intraflagellar transport trains

    Using a combination of cryo-electron tomography and structure prediction approaches, Lacey et al. reveal the molecular structure of IFT-A and IFT-B trains, providing insights into anterograde transport of cargo into the cilia tip.

    See Lacey et al.

  • No. 4 April 2023

    Adipokine leptin-induced receptor assembly

    Structural studies reveal how adipokine leptin induces trimerization of the leptin receptor in the hypothalamus to convey cellular signaling through the resulting cytokine–receptor assembly.

    See Tsirigotaki et al.

  • No. 3 March 2023

    PRPS1 assembles for allosteric activation

    A series of cryo-EM structures elucidate the function of PRPS1 filament formation from D3 symmetric hexamers, which stabilizes allosteric sites within the enzyme and promotes its activation.

    See Hvorecny et al.

  • No. 2 February 2023

    Regulation of Cas7-11 by TPR-CHAT

    The CRISPR-guided nuclease Cas7-11 forms a bird-like Craspase complex with the regulatory protease TPR-CHAT.

    See Ekundayo et al.

  • No. 1 January 2023

    A single rRNA modification gates ribosome assembly

    A single 2′-O-methylation of ribosomal RNA gates the assembly of a functional ribosome.

    See Yelland et al.