Accumulation of extrachromosomal telomere repeats in the cytoplasm activates the cGAS-STING pathway, and this mechanism is suppressed in ALT cancer cells. Image by Aleksandr Ugorenkov / Alamy Stock Photo. (p 1124)

Cryo-EM reconstructions of the small subunit processome provide essentially complete snapshots of the ribosome in construction. Cover image by Jonas Barandun. (pp 944 and 954)

A comprehensive proteomics screen reveals that the m6A RNA modification attracts and repels factors that control mammalian mRNA homeostasis. Cover by Erin Dewalt, image from Yon Marsh / Alamy Stock Photo. (p 870)

Api137, a derivative of the insect-produced antimicrobial peptide apidaecin, inhibits translation by trapping release factors 1 or 2 associated with ribosomes and arresting termination. Cover art by Erin Dewalt, image from Lorenzo Viola/EyeEm/Getty Images. (p 752)

Single-molecule force spectroscopy of titin fragments derived from ancestral sequence reconstruction and from modern animals offers insight into the evolution of titin's mechanical properties. Photograph taken by Raul Perez-Jimenez and Aitor Manteca at La Concha beach, San Sebastian, Spain. (p 652)

Structural and functional analyses of budding yeast Rif1 reveal a hooked N-terminal DNA-binding domain required for telomere maintenance and checkpoint control. Cover art by Erin Dewalt, image from Mgovantes / iStock / Getty Images Plus. (p 588)

Homotypic interactions between active or Polycomb-repressed promoters account for the 3D folding pattern at the HoxB locus. Cover art by Erin Dewalt, using origami imagery from Zoonar GmbH / Alamy Stock Photo. (p 515, News and Views p 494)

Cryo-EM and functional analyses reveal how ribosome splitting protein ABCE1 dissociates ribosomal subunits. Image from Cindy Goff / Alamy Stock Photo (p 453)

A 20S proteasome complex localizes to the neuronal plasma membrane, where it produces and releases extracellular peptides that induce neuronal signalling. Cover image from LuisPortugal /E+/Getty. (p 419)

Molecular chaperone HSP90 acts as a capacitor for genetic variation by influencing expression of murine ERVs and neighboring genes through the KAP1-SETDB1 epigenetic pathway. Cover image from Jurgis Mankauskas / Alamy Stock Photo. (p 234)

Structures of human APOBEC3A and an APOBEC3A/3B chimera bound to ssDNA reveal a U-shaped binding mode and provide insight into target selectivity. Cover shows the Moselschleife bei Bremm. Cover art by Erin Dewalt, image from studioworxx / iStock / Getty Images Plus. (p 131, News and Views p 97)

Barcoded HIV Ensembles (B-HIVE) provide a new approach to assess how the genomic location of viral integration influences proviral gene expression and reactivation in response to latency reversing agents. Cover image from Bill Brooks / Alamy Stock Photo. (p 47, News and Views p 8)