A PxL motif functions as a docking motif for substrates of yeast phosphatase Cdc14, contributing to the proper timing of dephosphorylation and ensuring orderly mitotic exit.

See Kataria et al. 25, 1093–1102 (2018)

Analyses of β-arches (loops connecting unpaired β-strands) yield rules used to design a de novo, hyperthermostable jellyroll structure.

See Marcos et al. 25, 1028–1034 (2018)

Bernstein and colleagues show that histone variant macroH2A is deposited across the mouse genome and subsequently pruned from transcriptionally active regions to establish macroH2A chromatin domains.

See Sun et al. 25, 958–970 (2018)

Natural compounds from the camphor tree, oregano, clove and thyme activate the TRPV3 channel. Cryo-EM analyses of mouse TRPV3 provide insights into gating mechanisms.

See Singh et al. 25, 805–813 (2018)

In crystallo catalysis studies of RNase H1 show additional cations position reactants for hydrolysis within the active site.

See Samara et al. 25, 715–721 (2018)

SYCP1, the core architectural element of the meiotic synaptonemal complex, forms tetrameric building blocks that assemble a zipper-like supramolecular lattice.

See Dunce et al. 25, 557–569 (2018)

Cardiomyopathy-causing mutations and small-molecule compounds alter the load dependence of human β-cardiac myosin detachment from actin.

See Liu et al. 25, 505–514 (2018)

Crystal structures capture the TRPV2 channel in a two-fold symmetric conformation, with the selectivity filter open wide, which would allow permeation of large organic cations.

See Zubcevic et al.

Using a novel approach, Akron-Seq, Mourelatos and colleagues show that mRNAs are subject to ribothrypsis: repeated, cotranslational, endonucleolytic cuts at the ribosome exit channel.

See Ibrahim et al.

2′-O-methylation within mRNA coding regions sterically perturbs interactions of ribosomal monitoring bases with cognate codon-anticodon helices.

See Choi et al. 25, 208-216 (2018)

The structure of the fully assembled yeast exocyst complex, which tethers secretory vesicles to the plasma membrane during exocytosis, provides new insights into complex assembly and the mechanism of vesicle tethering.

See Mei et al. 25, 139-146 (2018)

To mark NSMB’s 25th year, we have commissioned a special anniversary Series that celebrates the exciting research that we are proud to feature in NSMB. The Series begins with two Reviews in this issue, from Kobilka and colleagues and from Rossmann and colleagues.

See Editorial 25, 1 (2018)