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An artist's interpretation of how Pol E synthesizes DNA in the absence of a sliding clamp. The model is based on the cryo-EM structure of the Pol & multisubunit complex reported by Cheung et al. pp 35â43 (E. Boyle, oil on board)
Processing of a mammalian hematopoietic microRNA precursor is suppressed when it is edited by ADARs. The edited pri-miRNA can subsequently be degraded by Tudor-SN.
A recent study reveals that the chromatin-remodeling factor SWI/SNF regulates alternative splicing by creating internal 'roadblocks' to transcriptional elongation where the phosphorylation status of RNA pol II is qualitatively changed.
Decapping of messenger RNA was thought to involve a complex of only Dcp1 and Dcp2, but new data suggest that a larger multisubunit decapping complex exists in mammals. The larger complex includes a protein that facilitates the association of the two Dcp proteins and can be recruited by specific factors that promote mRNA decay.
An important link between Wnt binding at the cell surface and nuclear β-catenin–TCF–dependent transcription has been made with the identification of kinases that promote the association of the Wnt receptor and β-catenin turnover complexes. Surprisingly, the enzymes implicated had previously been suggested to inhibit rather than promote Wnt signaling.
