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Chromatin, transcript elongation and alternative splicing

Nature Structural & Molecular Biology volume 13, pages 5–7 (2006)Cite this article

A recent study reveals that the chromatin-remodeling factor SWI/SNF regulates alternative splicing by creating internal 'roadblocks' to transcriptional elongation where the phosphorylation status of RNA pol II is qualitatively changed.

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Figure 1: The kinetic coupling model for the regulation of alternative splicing by Pol II elongation.
Figure 2: SWI/SNF stimulates inclusion of alternative exons in the CD44 gene by creating a 'roadblock' to Pol II elongation at the variable region.

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  1. the Departamento de Fisiología y Biología Molecular, LFBM and IFIByNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, (C1428EHA), Buenos Aires, Argentina

    Alberto R Kornblihtt

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Kornblihtt, A. Chromatin, transcript elongation and alternative splicing. Nat Struct Mol Biol 13, 5–7 (2006). https://doi.org/10.1038/nsmb0106-5

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