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This Perspective focuses on five distinct regulatory elements that have been recognized as being critical for generating and modulating oscillatory dynamics in time and space, in both natural and synthetic biological networks.
This Perspective provides an overview of the major advances in recent years in the computational design and structure prediction of α-helical membrane proteins.
The use of nanodiscs is substantially fostering structural and functional studies of membrane protein. This Perspective summarizes the recent use of nanodiscs as an invaluable tool for the characterization of membrane proteins.
This Perspective provides an overview of recent progress, successes, challenges and future opportunities in the application of solution NMR and solid-state NMR methods to study the structure, dynamics and function of membrane proteins.
This Perspective discusses how two complementary approaches, bottom-up in vitro and top-down in situ structural biology, have now converged to generate the first predictive structural models of the nuclear pore scaffold.
This Perspective highlights recent progress on the location, functions and mechanisms of N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA. In particular, the authors discuss how m6A modification affects the mammalian RNA life cycle at multiple stages.