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Biochemical and genetic assays show that the nuclease Apn2 removes terminal cyclic phosphates that arise from ribonucleotide incorporation in the genome of budding yeast.
Transcriptional attenuation in response to heat shock is regulated by enhanced recruitment of N-TEFs to gene promoters, which depends on stress-activated kinase p38α and nascent-protein ubiquitination.
Structures of human 5-HT2AR in complex with several drugs reveal a side-extended cavity that is unique for this receptor, while molecular docking suggests that a highly 5-HT2AR-selective antagonist binds residues within this cavity.
A combination of bulk and single-molecule fluorescence analysis reveals the choreography of binding and rearrangement of individual DNA-binding domains of RPA during homologous recombination.
Assembly of proteasome subunits Rpt1 and Rpt2 is shown to occur co-translationally. Ribosomal pausing facilitates the incorporation of nascent Rpt1 and Rpt2 into Not-containing particles and their subsequent association with each other.
The noncoding RNA Xist regulates the accessibility of select chromatin regions on the inactive X chromosome (Xi) by directly inhibiting the chromosome remodeler BRG1 and by expelling it from the Xi.