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We launch a Series on Synaptic Processes, featuring commissioned Reviews and opinion pieces that discuss the expanding molecular understanding of how neural cells communicate.
The long non-coding RNA Xist induces heterochromatinization of the X chromosome by recruiting repressive protein complexes to chromatin. Here we gather evidence, from the literature and from computational analyses, showing that Xist assemblies are similar in size, shape and composition to phase-separated condensates, such as paraspeckles and stress granules. Given the progressive sequestration of Xist’s binding partners during X-chromosome inactivation, we formulate the hypothesis that Xist uses phase separation to perform its function.
This January 2018 issue starts the 25th year of NSMB’s journey. We mark the occasion by launching a special series that celebrates the exciting research uncovering the fundamental principles behind biological processes.
Nature research journals announce new reporting summaries to promote transparency, and our editors welcome early-career researchers to the Springer Nature office in New York to discuss careers in scientific publishing.
Daily rhythms are a constant part of life. This special Focus issue explores the molecular mechanisms that underlie the generation of circadian dynamics.