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JAK–cytokine receptor recognition, unboxed

Nature Structural & Molecular Biology volume 21, pages 431–433 (2014)Cite this article

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The crystal structure of the FERM-SH2 region of Tyk2 in complex with the cytoplasmic tail of an interferon-α receptor provides a first view of specific JAK-receptor recognition and reveals a central role of the heretofore-marginalized JAK SH2 domain in recognizing the cytokine-receptor box2 motif.

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Figure 1: The interferon-α receptor and its interactions with JAK kinases.
Figure 2: Sequence conservation among JAK family members across phylogeny, mapped onto the surface of the Tyk2 FERM-SH2 domain.

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Authors and Affiliations

  1. Randall McNally and Michael J. Eck are at the Department of Biological Chemistry and Molecular Pharmacology, and the Department of Cancer Biology, Harvard Medical School, Boston, Massachusetts, USA, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.,

    Randall McNally & Michael J Eck

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  1. Randall McNally
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Correspondence to Michael J Eck.

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Competing interests

MJE is a consultant for and receives research support from Novartis Institutes for BioMedical Research.

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McNally, R., Eck, M. JAK–cytokine receptor recognition, unboxed. Nat Struct Mol Biol 21, 431–433 (2014). https://doi.org/10.1038/nsmb.2824

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