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A wealth of prediction about the structure of spectrin has now been confirmed by the x-ray crystallographic analysis of a dimer of spectrin repeat units. The data provide a structural rationale for various haemolytic anaemias.
The common topology of the matrix metalloproteinase family, and details of the structures of individual members, will intensify efforts to develop drugs for diseases such as arthritis and cancer.
High-resolution structure analysis and directed mutagenesis experiments may at last be brought into step by the use of functional group analogues that alter individual atoms
Biochemical techniques provide a detailed picture of how the catalytic core of the Tetrahymena ribozyme interacts with the surface of its helical substrate.
To address important biological questions structural studies must be combined with quantitative methods of measurement and analysis derived from physics, chemistry and mathematics.
