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Positive surgical margins after partial nephrectomy

Nature Reviews Urology volume 7, pages 240–242 (2010)Cite this article

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Small renal tumors are generally managed by partial nephrectomy; however, positive surgical margins are occasionally found on final pathologic examination. Growing evidence suggests that the presence of positive margins does not adversely affect outcomes; these patients can potentially be managed expectantly with close follow-up without compromising oncological efficacy.

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References

  1. Rini, B. I., Campbell, S. C. & Escudier, B. Renal cell carcinoma. Lancet 373, 1119–1132 (2009).

    Article  CAS  Google Scholar 

  2. Timsit, M. O. et al. Prospective study of safety margins in partial nephrectomy: intraoperative assessment and contribution of frozen section analysis. Urology 67, 923–926 (2006).

    Article  PubMed  Google Scholar 

  3. Lam, J. S., Bergman, J., Breda, A. & Schulam, P. G. Importance of surgical margins in the management of renal cell carcinoma. Nat. Clin. Pract. Urol. 5, 308–317 (2008).

    Article  PubMed  Google Scholar 

  4. Lam, J. S. et al. Prognostic factors and selection for clinical studies of patients with kidney cancer. Crit. Rev. Oncol. Hematol. 65, 235–262 (2008).

    Article  PubMed  Google Scholar 

  5. Bensalah, K. et al. Positive surgical margin appears to have negligible impact on survival of renal cell carcinomas treated by nephron-sparing surgery. Eur. Urol. 57, 466–471 (2010).

    Article  PubMed  Google Scholar 

  6. Yossepowitch, O. et al. Positive surgical margins at partial nephrectomy: predictors and oncological outcomes. J. Urol. 179, 2158–2163 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Kwon, E. O., Carver, B. S., Snyder, M. E. & Russo, P. Impact of positive surgical margins in patients undergoing partial nephrectomy for renal cortical tumours. BJU Int. 99, 286–289 (2007).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany

    Sascha Pahernik & Markus Hohenfellner

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  1. Sascha Pahernik
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  2. Markus Hohenfellner
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Correspondence to Sascha Pahernik.

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The authors declare no competing financial interests.

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Pahernik, S., Hohenfellner, M. Positive surgical margins after partial nephrectomy. Nat Rev Urol 7, 240–242 (2010). https://doi.org/10.1038/nrurol.2010.58

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  • DOI: https://doi.org/10.1038/nrurol.2010.58

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