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The incidence of obesity, a potential risk factor for prostate disease, is rising sharply in the western world, as is the incidence of prostate tumors. In this extended Viewpoint, Kulkarni and Getzenberg propose that the relationship between obesity and prostate disease might be mediated by the autotaxin–lysophosphatidic acid (ATX–LPA) axis.
The treatment of prostate cancer is rapidly changing, and a new consensus for management is required. In this article, Oliver and Neal consider data from studies of hormone therapy, surgery, radiotherapy and active surveillance, and they discuss which options might be suitable in which patients.
This second Viewpoint on the issue of neonatal circumcision discusses why this practice might not be beneficial. Van Howe refutes claims that circumcision has a protective effect from genital cancer, urinary tract infections and sexually transmitted infections, and highlights the many adverse events that can be experienced following circumcision.
