Collections

Filters ​

  • Focus |

    Traumatic brain injury (TBI) is a major cause of lifelong disability and death worldwide, but is considered a 'silent epidemic' as society is largely unaware of the magnitude of the problem. Repetitive brain injuries can cause a neurodegenerative disorder termed chronic traumatic encephalopathy (CTE), as has been highly publicized in recent years in cases of retired participants of high-impact sports such as boxing and American football. In this special Focus Issue, experts in TBI and CTE review the causes, pathology, consequences and epidemiology of brain injury, as well as highlighting advances in prevention, detection and monitoring of TBI.

  • Focus |

    Multiple sclerosis (MS) is an inflammatory, demyelinating neurological disease that causes severe disability. Current treatments are only partially effective, and No. cure is available. This issue of the journal focuses on disease mechanisms that operate in different phases in MS—including initiation, exacerbation, remyelination and functional recovery, and progression—placing the latest findings in a clinical context, including implications for therapy.

  • Collection |

    Stroke is the second most common cause of death worldwide and a major source of morbidity. Stroke is strongly associated with atrial fibrillation, the most prevalent cardiac arrhythmia, and with transcatheter aortic valve therapeutics, the use of which is becoming more widespread. This collection of articles from Nature Reviews CardiologyandNature Reviews Neurologycomprises a selection of three Reviews, one Perspectives article and five News & Views, which explore advances in our understanding of the pathophysiology, assessment, prevention and management of ischemic stroke.

  • Focus |

    Amyotrophic lateral sclerosis (ALS) is a neurodegenerative motor neuron disease that presents substantial diagnostic and therapeutic challenges. In this focus issue, experts highlight recent progress in understanding the genetic and molecular underpinnings of ALS, including the discovery of biomarkers for rapid diagnosis of the condition and monitoring of disease progression. Current and future treatment and management approaches are also addressed, along with prospects for improving the design of clinical trials in ALS.

  • Focus |

    The field of neuroinformatics was originally conceived as the application of information technology to the compilation, integration and analysis of large data sets in basic neuroscience research. In this special issue, we explore how the principles of neuroinformatics are now being extended to the neurology clinic, highlighting initiatives in three diverse areas: glioma genomics, neurocritical care, and brain imaging in neurodegenerative disease.

  • Collection |

    Multiple sclerosis is an inflammatory disease of the CNS characterized by demyelinating lesions and axonal damage, and is the most common cause of neurological disability among young adults. This collection brings together international experts on a range of aspects of multiple sclerosis, including genetics, imaging, epidemiology, and new approaches to treatment.

  • Focus |

    With the growth of the aged population, the socioeconomic costs of dementia are set to rise sharply. No. disease-modifying drugs currently exist for the main cause of dementia, namely Alzheimer disease. The successful development of such drugs, and disease-modifying therapies for other causes of dementia, will require the ability to make an early diagnosis of the disease and a means to monitor the progression of pathology in vivo, in addition to novel agents. In this Focus issue, leading experts examine pharmacological strategies that are being explored to combat Alzheimer disease and biomarkers that are being developed for this disorder and other causes of dementia.