The field of neuroinformatics was originally conceived as the application of information technology to the compilation, integration and analysis of large data sets in basic neuroscience research. In this special issue, we explore how the principles of neuroinformatics are now being extended to the neurology clinic, highlighting initiatives in three diverse areas: glioma genomics, neurocritical care, and brain imaging in neurodegenerative disease.
EDITORIAL
A rapid e-volution
Heather Wood
doi:10.1038/nrneurol.2011.115
Nature Reviews Neurology 7, 415 (2011)
REVIEWS
Virtual imaging laboratories for marker discovery in neurodegenerative diseases
Giovanni B. Frisoni, Alberto Redolfi, David Manset, Marc-Étienne Rousseau, Arthur Toga & Alan C. Evans
doi:10.1038/nrneurol.2011.99
Nature Reviews Neurology 7, 429-438 (2011)
Research in neurodegenerative disease is generating vast neuroimaging data sets, necessitating the development of powerful new e-infrastructures for data collection, storage, access and analysis. In this article, Frisoni et al. provide an overview of the currently available e-infrastructures—LONI, neuGRID and CBRAIN—and consider how computational neuroscience in neurodegenerative disease might evolve in the future.
Integration and analysis of genome-scale data from gliomas
Gregory Riddick & Howard A. Fine
doi:10.1038/nrneurol.2011.100
Nature Reviews Neurology 7, 439-450 (2011)
Malignant brain tumors such as glioma have a poor prognosis. Large-scale efforts to compile and store genome-wide data on gliomas have recently been initiated. Riddick and Fine describe these key initiatives and how these genomic approaches aim to improve tumor classification and elucidate the underlying biology of glioma. Use of these genomic technologies in the development of new diagnostic and therapeutic strategies in personalized medicine will also be discussed.
Multimodal monitoring and neurocritical care bioinformatics
J. Claude Hemphill, Peter Andrews & Michael De Georgia
doi:10.1038/nrneurol.2011.101
Nature Reviews Neurology 7, 451-460 (2011)
Monitoring for secondary brain injury is central to neurocritical care. Hemphill and colleagues provide an overview of multimodal monitoring in neurocritical care and discuss how bioinformatics tools for data acquisition, analysis and storage could be used in the clinical management of patients with acute brain injuries.
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