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Alzheimer disease is a complex and multifactorial condition. The authors of this Perspective suggest that its lack of a singular common pathogenesis prevents it from being regarded as a straightforward ‘disease’ and that treatment will therefore require a multifaceted approach.
In this Perspective, the authors discuss the need for neurologists to assist in court cases involving criminal behaviour that was potentially influenced by a neurological disorder. The authors review evidence linking neurological disorders with criminal activity, and advocate for the development of forensic neurology as a subspecialty of the field.
In this Perspective, Zech and Winkelmann outline multidimensional strategies for genetic diagnosis in patients with rare movement disorders and highlight community-driven data-sharing and case-matchmaking platforms designed to foster the discovery of new genotype–phenotype relationships.
