Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Huntington's disease (HD) accounts for around 90% of cases of chorea of genetic etiology, but a number of other distinct genetic disorders can present with a clinical picture indistinguishable from HD. In this article, Schneider et al. review the clinical features and genetic bases of these HD-like syndromes, discussing the clinical clues that should prompt further investigations in patients presenting with these conditions.
Activation of the ligand-inducible transcription factor peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to suppress inflammation in peripheral macrophages and in models of human autoimmune disease. As Heneka et al. discuss in this Review, PPARγ is now being investigated as a potential therapeutic target in CNS disorders with an inflammatory component, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and multiple sclerosis.
In children, nonconvulsive status epilepticus (NCSE) is associated with various conditions, including acute neurological injuries and specific childhood epilepsy syndromes, and it can also be observed in individuals with learning difficulties. In this article, Korff and Nordli review various aspects of NCSE, including clinical and electroencephalographic features, prognosis, and treatment recommendations. They also highlight the need for further research into NCSE in pediatric populations.
Recent data show that MRI at term-equivalent age can predict neurodevelopmental outcomes in infants born far before term. So should cranial MRI screening replace cranial ultrasound in preterm babies? The authors of this Viewpoint weigh up the options.