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New research shows that variants in two FTD–ALS risk genes impair the functioning of the endolysosomal pathway, leading to pathological intracellular accumulation of TDP43 protein.
A new report shows that chronic pain leads to accumulation of pathological forms of tau protein in the hippocampus, resulting in neuronal atrophy and cognitive impairment.
A new study indicates that cerebrospinal fluid levels of specific reactive astrocyte biomarkers reflect different Alzheimer disease pathologies in the brain.
Two research teams in China have developed new local therapy approaches that are designed to eliminate brain tumour cells while minimizing damage to the surrounding healthy tissue.
A new study has shown that a modulator of metabotropic glutamate receptor 5 can reverse synapse loss in mouse models of Alzheimer disease and has the potential to be developed as a disease-modifying treatment for this condition.
New research shows that meningeal lymphatic vessels can drain viruses from the CNS, with important implications for our understanding of CNS infections.
A new study provides evidence that inflammation protects against the development of chronic pain in people with acute back pain, and that anti-inflammatory drugs used to treat acute pain could do more harm than good in the long term.