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A new report shows that chronic pain leads to accumulation of pathological forms of tau protein in the hippocampus, resulting in neuronal atrophy and cognitive impairment.
New work building on the results of genome-wide association studies in Alzheimer disease has identified molecular mechanisms that are shared with some psychiatric disorders. The study leveraged ‘omics data and has the realistic potential to elucidate unknown disease mechanisms; however, a lack of information about neuropsychiatric symptoms in the participants with Alzheimer disease limits the conclusions.
In this Review, the authors summarize the interactions of the neurovascular unit with systemic biology after ischaemic stroke, consider how these interactions influence stroke outcome, and discuss how these interactions could be targeted to improve outcomes.
In this Perspective article, the authors outline how studying multiple sclerosis (MS) genetics in ancestrally diverse populations is likely to yield insights that could benefit individuals with MS from all ancestral groups.
In this Perspective, Fiorio et al. discuss the relationship between functional neurological disorder and placebo and nocebo effects, with the aim of providing insights into the pathogenesis of the disorder and identifying potential therapeutic targets.
In this Review, Fong and Inouye explore mechanisms that might be common to both delirium and dementia. They present delirium as a possible modifiable risk factor for dementia and discuss the importance of delirium prevention strategies in reducing this risk.
A new study indicates that cerebrospinal fluid levels of specific reactive astrocyte biomarkers reflect different Alzheimer disease pathologies in the brain.
Responding to increasing concerns around adverse brain health outcomes among former football (soccer) players, the Football Association of England recently announced a trial ban on heading in matches for players aged under 12 years. This is a step in the right direction, but wider interventions to preserve brain health should not be forgotten.
Numerous studies have attempted to identify pathogenic autoantibodies in people with multiple sclerosis (MS), but their results are conflicting. In this Perspective, the authors explore the available evidence and provide their own opinions on a possible role for autoantibodies in MS.
Two research teams in China have developed new local therapy approaches that are designed to eliminate brain tumour cells while minimizing damage to the surrounding healthy tissue.