Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Concerns regarding the incorrect use of race as a biological construct and the resulting negative effect on health equity have led to reconsideration of the inclusion of race in equations for estimating glomerular filtration rate. Now, two studies report that cystatin-C-based equations can accurately estimate glomerular filtration rate independent of race.
Dapagliflozin reduces the risk of new-onset diabetes mellitus, according to results from a pre-specified pooled analysis of the DAPA-CKD and DAPA-HF trials. The study adds to the growing list of sodium–glucose co-transporter 2 inhibitor benefits and raises the possibility of an expanded target patient population.
A recent clinical trial reports promising efficacy and safety data for belzutifan in patients with von Hippel–Lindau (VHL) disease–associated renal cell carcinoma. On the basis of these results, belzutifan became the first therapeutic agent to be approved for the systemic treatment of cancer associated with VHL disease.
Cockayne syndrome is a genetic disease characterized by impairment of DNA repair mechanisms, premature ageing, cachexia and kidney dysfunction. New research in a mouse model of Cockayne syndrome demonstrates that injury induces a subset of kidney proximal tubule cells to express the anorexigenic peptide GDF15. These findings link kidney injury to cachexia and highlight the role of the kidney in mediating inter-organ homeostasis.
Tissue-resident memory T cells are crucial to immune responses in epithelial and mucosal tissues. This Review examines the unique characteristics and differentiation pathways of these cells, as well as their unique adaptations in the urogenital tract, and their role in infection, cancer, inflammatory diseases and transplantation.
Mutations in ~35 genes have been identified as monogenic causes of kidney stone disease, and gene variants have been associated with stone disease in the general population. Here, the authors discuss the genetic and molecular basis of kidney stone disease and nephrocalcinosis.
Here, the authors review current approaches to replication of the glomerulus in vitro with a focus on organ-on-a-chip, scaffolding and organoid technologies. They also discuss future directions of research, including the use of newer 3D biofabrication technologies.
‘Metabolic dysfunction-associated fatty liver disease’ has been proposed as a replacement term for ‘Non-alcoholic fatty liver disease’, in part to recognize the fact that this liver disease occurs within a series of complex metabolic disorders. This Perspective article discusses the clinical associations and pathophysiological mechanisms underpinning the relationship between metabolic dysfunction-associated fatty liver disease and chronic kidney disease.
