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Kidney disease is an underappreciated medical complication of anorexia nervosa. Further research is needed to clarify the mechanisms that drive kidney disease in patients who restrict caloric intake or engage in purging. Education and awareness are also needed, because kidney disease is often under-recognized by these patients and their clinicians.
Chronic kidney disease (CKD) is often well advanced before it is detected. Although polygenic scores may enable the early stratification of patients at risk of CKD, the transferability of polygenic scores for the prediction of CKD to populations of non-European ancestry was limited. A new cross-ancestry polygenic score for CKD overcomes these issues, demonstrating good performance across ancestries.
Low nephron number is a risk factor for the development of hypertension, chronic kidney disease and kidney failure. This Review describes the mechanisms that modulate nephrogenesis and the timing of nephrogenesis cessation, focusing on environmental and intrinsic pathways that may be manipulated to enhance nephron endowment in susceptible individuals.
Chronic kidney disease (CKD) is associated with an elevated risk of cardiovascular disease (CVD). Here, the authors examine CKD-associated risk factors for CVD and consider the prediction and management of CVD risk in patients with CKD, including research and implementation gaps.
Effective vaccination strategies are crucial to mitigate the high risk of infection-associated morbidity and mortality in patients with kidney failure. Here, the authors examine vaccine-induced immunity in these patients, in particular their responses to COVID-19 vaccination, in the context of the immune impairment induced by kidney dysfunction and the use of immunosuppressive medications.
In this Review, the authors summarize the challenges associated with the care of patients with kidney disease during the COVID-19 pandemic. They describe the major challenges and missed opportunities, global inequalities in health care, and offer a framework for future pandemic preparedness.
