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Millions of people in under-privileged regions of the world continue to drink heavily polluted water and die from diarrhoea-related acute kidney injury whilst world super-powers continue to offer military aid to these regions. This gun aid must convert into water aid.
The nephrology community is increasingly being confronted with the challenge of caring for refugees with kidney disease. An urgent need exists for a global registry of these patients as well as consistent guidance for financial, cultural and ethical issues in order to ensure that they receive sustainable and equitable care.
Planar cell polarity (PCP) refers to the coordinated orientation of cells in the tissue plane and is important for several key morphogenetic and homeostatic processes. This Review describes the origins of PCP signalling, its activity and cellular targets, with an emphasis on the PCP pathway in kidney development, function and disease.
Patients with haematological cancer are at risk of kidney injury, whether as a direct consequence of the malignancy or because of treatment-related effects. Here, the authors review the most common causes of kidney injury in these patients and discuss their pathophysiology, presentation and management.
Chronic kidney disease is characterized by the retention of uraemic toxins, which can damage organs, including the cardiovascular system. Removal of these toxins by current dialysis modalities is inadequate, highlighting a need for new strategies. This Review summarizes pharmacological and non-pharmacological means of abrogating the effects of uraemic toxins.
Calcium oxalate kidney stones are often found attached to Randall’s plaques in the kidney papilla. Here, the authors examine the mechanisms underlying the formation of Randall’s plaques, including the role of mineralization modulators, as well as inflammation and immune cells.
