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Mesangial cells are stromal cells that are important for kidney glomerular homeostasis and the glomerular response to injury. This Perspective reviews advances in our understanding of mesenchymal stromal cell function and describes how these insights can inform our understanding of mesangial cells and their role in disease.
Focal segmental glomerulosclerosis is a histopathological lesion that has heterogeneous causes. In this Perspectives article, the authors outline a rationale for the stratification of focal segmental glomerulosclerosis based on current understanding of the pathophysiology of podocyte stress and damage and propose that such an approach will improve the rational design and success of therapeutic trials.
The concepts of kidney damage and dysfunction, including subclinical damage and loss of renal functional reserve, are relevant to the detection of acute kidney injury (AKI). Here, the authors examine these concepts, as well as AKI duration and relapse, and discuss potential changes to AKI classification criteria.
