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Hyperreninemic hypertension is a clinical condition in which the kidneys produce too much renin autonomously and independently of angiotensin II and aldosterone levels. This Case Study reports the case of a previously normotensive 18-year-old man who developed renin-dependent hypertension following presumed sports-related blunt renal trauma. The diagnosis, treatment and management of this patient are discussed.
This article reports the case of a 73-year-old man who developed spondylodiscitis as a result of methicillin-sensitiveStaphylococcus aureusbacteremia. The patient's catheter was identified as the source of bacteremia, which had spread to the vertebral discs as confirmed by microbiological tests and MRI. The authors also discuss the characteristics of 12 other patients with spondylodiscitis and describe the risk factors for developing this condition and its most appropriate management.
This article reports the case of a 50-year-old man who had undergone kidney and pancreas transplantation and developed pancytopenia following treatment with azathioprine. A genotype test for thiopurineS-methyltransferase (TPMT) showed that the patient was homozygous for TPMT*3A, which accounted for the susceptibility to azathioprine-related myelosuppression. The authors discuss the importance of TPMT testing and describe the tools available for monitoring for adverse effects from treatment.
