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  • Case Study
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Hyperreninemic hypertension following presumed abdominal trauma

Abstract

Background. An 18-year-old previously normotensive man was referred to a hypertension unit with blood pressure readings of 140–150/100–110 mmHg. Renal ultrasound had shown a right renal subcapsular fluid collection and an abdominal computed tomography scan had revealed a large cystic lesion surrounding the right kidney with a thick wall and irregular peripheral calcification consistent with a long-standing traumatic perinephric hematoma.

Investigations. Physical examination, renal artery duplex ultrasonography, magnetic resonance imaging of the abdomen, isotopic renography with technetium-99m diethylenetriamine pentaacetic acid, and a renal venous renin ratio study.

Diagnosis. Hyperreninemic hypertension as a result of presumed abdominal trauma.

Management. Removal of the affected kidney.

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Figure 1: T2-weighted magnetic resonance images of the abdomen.
Figure 2: Isotopic renography technetium-99m diethylenetriamine pentaacetic acid image showing reduced function and perfusion of the right kidney.

References

  1. Pimenta, E., Calhoun, D. A. & Oparil, S. in Cardiology (eds Crawford, M. H., DiMarco, J. P. & Paulus, W. J.) 511–522 (Elsevier, Philadelphia, 2009).

    Google Scholar 

  2. Tigerstedt, R. & Bergman, P. G. Niere und kreislauf [German]. Skand. Arch. Physiol. 8, 223–271 (1898).

    Article  Google Scholar 

  3. Goldblatt, H., Lynch, J., Hanzal, R. F. & Summerville, W. W. Studies on experimental hypertension: I. the production of persistent elevation of systolic blood pressure by means of renal ischemia. J. Exp. Med. 59, 347–379 (1934).

    Article  CAS  Google Scholar 

  4. Page, I. H. A method for producing persistent hypertension by cellophane. Science 89, 273–274 (1939).

    Article  CAS  Google Scholar 

  5. Page, I. H. On the nature of the pressor action of renin. J. Exp. Med. 70, 521–542 (1939).

    Article  CAS  Google Scholar 

  6. Page, I. H. The production of persistent arterial hypertension by cellophane perinephritis. JAMA 113, 3 (1939).

    Google Scholar 

  7. Grollman, A. Experimental hypertension in the dog. Am. J. Physiol. 147, 647–653 (1946).

    Article  CAS  Google Scholar 

  8. Haab, F., Duclos, J. M., Guyenne, T., Plouin, P. F. & Corvol, P. Renin secreting tumors: diagnosis, conservative surgical approach and long-term results. J. Urol. 153, 1781–1784 (1995).

    Article  CAS  Google Scholar 

  9. Campese, V. M., Mitra, N. & Sandee, D. Hypertension in renal parenchymal disease: why is it so resistant to treatment? Kidney Int. 69, 967–973 (2006).

    Article  CAS  Google Scholar 

  10. Grantham, J. J. Clinical practice. Autosomal dominant polycystic kidney disease. N. Engl. J. Med. 359, 1477–1485 (2008).

    Article  CAS  Google Scholar 

  11. Chedid, A. et al. Blunt renal trauma-induced hypertension: prevalence, presentation, and outcome. Am. J. Hypertens. 19, 500–504 (2006).

    Article  Google Scholar 

  12. Montgomery, R. C., Richardson, J. D. & Harty, J. I. Posttraumatic renovascular hypertension after occult renal injury. J. Trauma 45, 106–110 (1998).

    Article  CAS  Google Scholar 

  13. Knudson, M. M. et al. Outcome after major renovascular injuries: a Western trauma association multicenter report. J. Trauma 49, 1116–1122 (2000).

    Article  CAS  Google Scholar 

  14. Engel, W. J. & Page, I. H. Hypertension due to renal compression resulting from subcapsular hematoma. J. Urol. 73, 735–739 (1955).

    Article  CAS  Google Scholar 

  15. McCune, T. R., Stone, W. J. & Breyer, J. A. Page kidney: case report and review of the literature. Am. J. Kidney Dis. 18, 593–599 (1991).

    Article  CAS  Google Scholar 

  16. Dopson, S. J., Jayakumar, S. & Velez, J. C. Page kidney as a rare cause of hypertension: case report and review of the literature. Am. J. Kidney Dis. 54, 334–339 (2009).

    Article  Google Scholar 

  17. Tillou, A. et al. Renal vascular injuries. Surg. Clin. North Am. 81, 1417–1430 (2001).

    Article  CAS  Google Scholar 

  18. Bruce, L. M. et al. Blunt renal artery injury: incidence, diagnosis, and management. Am. Surg. 67, 550–554; discussion 555–556 (2001).

    CAS  PubMed  Google Scholar 

  19. McPhaul, J. J. Jr et al. Remediable hypertension due to unilateral renal disease: correlation of split renal-function tests and pressor assays of renal venous blood in hypertensive patients. Arch. Intern. Med. 115, 644–651 (1965).

    Article  Google Scholar 

  20. Kirkendall, W. M., Fitz, A. E. & Lawrence, M. S. Renal hypertension. Diagnosis and surgical treatment. N. Engl. J. Med. 276, 479–485 (1967).

    Article  CAS  Google Scholar 

  21. Gordon, R. D., Tunny, T. J., Evans, E. B., Fisher, P. M. & Jackson, R. V. Unstimulated renal venous renin ratio predicts improvement in hypertension following nephrectomy for unilateral renal disease. Nephron 44 (Suppl. 1), 25–28 (1986).

    Article  Google Scholar 

  22. Michelakis, A. M. et al. Measurement of renin in both renal veins. Its use in diagnosis of renovascular hypertension. Arch. Intern. Med. 120, 444–448 (1967).

    Article  CAS  Google Scholar 

  23. Tunny, T. J., Klemm, S. A., Hamlet, S. M. & Gordon, R. D. Diagnosis of unilateral renovascular hypertension: comparative effect of intravenous enalaprilat and oral captopril. J. Urol. 140, 713–715 (1988).

    Article  CAS  Google Scholar 

  24. Brenner, B. M., Meyer, T. W. & Hostetter, T. H. Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N. Engl. J. Med. 307, 652–659 (1982).

    Article  CAS  Google Scholar 

  25. Brenner, B. M. Hemodynamically mediated glomerular injury and the progressive nature of kidney disease. Kidney Int. 23, 647–655 (1983).

    Article  CAS  Google Scholar 

  26. Robitaille, P., Mongeau, J. G., Lortie, L. & Sinnassamy, P. Long-term follow-up of patients who underwent unilateral nephrectomy in childhood. Lancet 1, 1297–1299 (1985).

    Article  CAS  Google Scholar 

  27. Bock, H. A., Bachofen, M., Landmann, J. & Thiel, G. Glomerular hyperfiltration after unilateral nephrectomy in living kidney donors. Transpl. Int. 5 (Suppl. 1), S156–S159 (1992).

    Article  Google Scholar 

  28. Haas, C. A. & Spirnak, J. P. Traumatic renal artery occlusion: a review of the literature. Tech. Urol. 4, 1–11 (1998).

    CAS  PubMed  Google Scholar 

  29. Haas, C. A., Dinchman, K. H., Nasrallah, P. F. & Spirnak, J. P. Traumatic renal artery occlusion: a 15-year review. J. Trauma 45, 557–561 (1998).

    Article  CAS  Google Scholar 

  30. Long, J. A. et al. Traumatic dissection of the renal pedicle. Modalities of management in adults and children [French]. Prog. Urol. 14, 302–309; discussion 308 (2004).

    PubMed  Google Scholar 

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Acknowledgements

Written consent for publication was obtained from the patient. C. P. Vega, University of California, Irvine, CA, is the author of and is solely responsible for the content of the learning objectives, questions and answers of the Medscape, LLC-accredited continuing medical education activity associated with this article.

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E. Pimenta, R. D. Gordon and M. Stowasser wrote the article. All of the authors contributed to researching data for the article, discussing the content and reviewing/editing the manuscript before submission.

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Correspondence to Eduardo Pimenta.

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The authors declare no competing financial interests.

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Pimenta, E., Gordon, R., Daunt, N. et al. Hyperreninemic hypertension following presumed abdominal trauma. Nat Rev Nephrol 7, 730–734 (2011). https://doi.org/10.1038/nrneph.2011.127

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