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Regenerative neurogenesis after spinal cord injury in zebrafish involves TNF signalling between lesion-activated macrophages and spinal progenitor cells.
Neocortical circuits imparting specificity and causality to pain are not well understood. In this Review, Kuner and Tan discuss new insights into the contributions of diverse cerebral domains, their connectivity and their plasticity to the sensory and emotional aspects of pain.
The capacity to navigate to a previously encountered or predicted reward, such as food or safety, is crucial for survival. Here, Sosa and Giocomo examine the neural mechanisms that encode reward location and propose key roles for the hippocampus and the entorhinal cortex in storing and retrieving reward-related information in the brain.
Neural network models have potential for improving our understanding of brain functions. In this Perspective, Pulvermüller and colleagues examine various aspects of such models that may need to be constrained to make them more neurobiologically realistic and therefore better tools for understanding brain function.
Regions of the default mode network (DMN) are distributed across the brain and show patterns of activity that have linked them to various different functional domains. In this Perspective, Smallwood and colleagues consider how an examination of the topographic characteristics of the DMN can shed light on its contribution to cognition.
