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Specific subpopulations of vagal mechanoreceptors that sense intestinal stretch are identified by transcriptomic approaches and are shown to induce satiety.
Two studies show that, compared with microglia in anaesthetized mice, microglia in awake mice show reduced surveillance owing to an increase in noradrenaline signalling.
Although the retinas of most vertebrates share the same basic blueprint, there is substantial variability in their detailed structure and function. Baden and colleagues describe the extent of this diversity and explore the factors that contribute to species-specific adaptations in retinal organization.
In Alzheimer disease, the accumulation of amyloid-β (Aβ) is thought to drive both tau pathology and neurodegeneration. In this Review, van der Kant et al. discuss the evidence for Aβ-independent drivers of tau pathology in Alzheimer disease and the implications for therapeutic development.
The impact of RNA modifications, such as RNA methylation, on gene expression and cellular function has been the subject of recent intense investigations. Here Dominissini and colleagues provide an overview of the mechanisms of such epitranscriptomic regulation and their functional consequences in the nervous system.
