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Although chronic pain is one of the most important medical problems facing society, there has been very limited progress in the development of novel therapies for this condition. Here, we discuss high-impact research priorities to reduce the number of people transitioning from acute to chronic intractable pain.
In mice with experimental autoimmune encephalitis, dietary metabolites of tryptophan may modulate the activities of glia to influence neuroinflammation.
Opiate drugs and opioid peptides differ in their effects on intracellular signalling, in which following ligand–receptor binding and internalization, opioids continue to signal from endosomes, whereas opiates activate receptors located at the Golgi.
Gliomas represent the most deadly of human brain tumours; however, little progress has been made towards their successful treatment. In this Review, Deneen and colleagues discuss how glioma tumorigenesis resembles glial development and how this may inform novel therapies.
Decision-making requires us to correctly evaluate the likely outcomes of our choices. Murray and Rudebeck describe how evidence from lesion and neurophysiology studies in non-human primates has given us insight into the specific contributions of prefrontal cortex subdivisions in this process.
In this Opinion article, Mobbs and colleagues argue that more should be done to combine the approaches taken in neuroscience with those taken in ethology and behavioural ecology to study decision-making. They illustrate how this has been achieved in the context of studies on foraging.
A growing field of research seeks to establish a neuroscientific basis for the correlations between socioeconomic status and life outcomes. Farah evaluates the opportunities and challenges that face the application of this field to wider policy discussions.
