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  • Although chronic pain is one of the most important medical problems facing society, there has been very limited progress in the development of novel therapies for this condition. Here, we discuss high-impact research priorities to reduce the number of people transitioning from acute to chronic intractable pain.

    • Theodore J. Price
    • Allan I. Basbaum
    • Robert H. Dworkin
    Comment
  • Brain implants are being trialled for their potential to ameliorate treatment-resistant conditions or to restore function. However, there are no clear guidelines for continued access to brain implants for trial participants whose symptoms improve with these devices.

    • Gabriel Lázaro-Muñoz
    • Daniel Yoshor
    • Amy L. McGuire
    Comment