News & Comment

Molecular changes in blood that occur with ageing may be partly responsible for the decreased neurogenesis and cognitive deficits that are observed in aged mice.

Chronic ingestion of probiotic ('good') bacteria can reduce anxiety, an effect that seems likely to be mediated via the vagus nerve.

The effects of prenatal stress on sex differences in brain gene expression and behaviour can be transmitted down the paternal lineage to male offspring.

A new study shows that in its native state, α-synuclein predominantly exists as an α-helical tetramer rather than an unfolded monomer.

The synaptic vesicle protein RAB3B seems to have a key role in endocannabinoid-dependent presynaptic long-term depression at hippocampal inhibitory synapses and also in spatial memory retention.

The retrograde transport of signalling endosomes requires the activation of RAC1and cofilin to induce actin depolymerization.

Grid cells and place cells encode little information about vertical position in three-dimensional space.

During the synaptic maturation and elimination phase of hippocampal development, microglia may engulf unwanted synapses, and thus contribute to correct circuit maturation.

Reducing adult neurogenesis induces depression-like behaviour under stressful conditions.

A novel function for CaMKIIβ has been identified in the mammalian brain whereby it regulates dendritic patterning through phosphorylation of CDC20–APC/C at the centrosome.

A new study reveals the physiological basis of age-related memory decline and potential means to restore it.

An elevation in the excitation/inhibition ratio in the medial prefrontal cortex leads to impairments in social behaviour and cognition in mice.

Loss of delta-like homologue 1 (Dlk1) imprinting in the subventricular zone regulates postnatal neurogenesis.

A multisynaptic pathway from the hippocampal CA3 via the lateral septum to the ventral tegmental area links spatial context to reward.

Schema-dependent memory formation involves parallel encoding in the hippocampus and in the neocortex.

Death receptor 6 negatively regulates the survival and maturation of oligodendrocytes and limits remyelination.

Social stress processing in healthy individuals is affected by city living and an urban upbringing

Rare copy number variations explain a relatively large proportion of sporadic cases of autism spectrum disorders.

Immune factors mediate the effect of circadian disruption on depression-like behaviour

Loneliness increases aggressiveness, even in flies