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Amyloid-β and tau exert toxicity in Alzheimer's disease through mechanisms that are gradually becoming understood. This Progress article reviews recent findings regarding their possible interactions and synergistic effects at the synapse, and discusses how these effects may contribute to the pathogenesis of Alzheimer's disease.
In this Progress article, Sacktor highlights the key role of protein kinase Mζ (PKMζ) — the constitutively active protein kinase C isoform — in perpetuating the synaptic events underlying long-term memory, and proposes a model of 'synaptic autotagging' by which this enzyme maintains its localization at the synapse.
Recent evidence suggests that mutations inLRRK2are linked to Parkinson's disease. In this Progress article, Mark Cookson discusses how these mutations might affect LRRK2 function and its interactions with other proteins that have been implicated in Parkinson's disease, specifically α-synuclein and tau.
Glucocorticoid hormones modulate the acquisition and consolidation of memories of stressful events. Krugers and colleagues review recent evidence that glucocorticoids achieve this through rapid and persistent effects on AMPA receptors by activation of mineralocorticoid receptors and glucocorticoid receptors, respectively.
