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Autoantibodies against neuromuscular junction targets are a well-established cause of myasthenic syndromes, and autoantibodies against CNS targets have also been associated with disease. In this Review, Vincent and colleagues discuss key examples of such autoantibodies, and the mechanisms by which they lead to neurological dysfunction.
Training involving repeated long inter-trial intervals — spaced training — leads to more robust memory formation for many types of learning than does training involving short or no intervals. This Review examines the learning theories and the molecular and cellular mechanisms that may account for the effectiveness of spaced training.
CA2 has several characteristics that distinguishes it from CA1 and CA3. In this Review, Dudek and colleagues discuss an updated definition of the CA2 boundaries, and provide an overview of the unique synaptic properties and behavioural functions of this region.
