Research Highlights in 2010

A population of neurons in the somatosensory cortex responds specifically to the direction of a moving tactile stimulus.

D-serine release from astrocytes induces LTP in hippocampal slices.

High-throughput screens have been developed to assess the effects of drugs on behaviour in zebrafish.

Neuronal expression of PrP^Cis required for the maintenance of the myelin sheaths around peripheral nerves.

Coadministration of α₂-adrenoceptor antagonists accelerates the effects of antidepressants.

GABAergic interneurons were identified as hub cells that trigger network synchronization in the hippocampus.

Inflammation-induced nuclear export of HDAC1 disrupts axonal transport of mitochondria, initiating axonal damage in models of demyelinating diseases.

LRRTM2 drives presynaptic and postsynaptic synapse assembly and is a ligand for neurexin 1

The switch from attraction to repulsion downstream of cAMP depends on a switch from EPAC- to PKA-mediated signalling.

MicroRNA 206 promotes muscle reinnervation in a mouse model of amyotrophic lateral sclerosis

Fear memories can be blocked in humans by updating them during a window of reconsolidation with new, non-fear-related information.

Future activity in individual neurons can be predicted from past activity of small ensembles.

Cadherin-2 drives the directional migration of granule cells during cerebellar development.

Enhanced tonic inhibition causes seizures in several animal models of epilepsy.

Cannabidiol attenuates cue-induced drug-seeking behaviour in heroin-addicted rats.