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  • Modern approaches for multiregion investigation provide new opportunities and considerations for exploring brainwide neural dynamics. In this Review, Machado, Kauvar and Deisseroth discuss advances in the simultaneous measurement and analysis of neuronal activity across many brain regions.

    • Timothy A. Machado
    • Isaac V. Kauvar
    • Karl Deisseroth
    Review Article
  • The progenitor cell populations that establish the developing human cortex exhibit distinct forms of apical–basal polarity. Kriegstein and colleagues review the mechanisms that regulate human cortical progenitor polarity, its importance for cortical development and the consequences of its disruption in neurological disorders.

    • Madeline G. Andrews
    • Lakshmi Subramanian
    • Arnold R. Kriegstein
    Review Article
  • The modern human variant of the gene transketolase-like 1, but not the Neanderthal variant, promotes the production of basal radial glia during neocortical development.

    • Darran Yates
    Research Highlight
  • Axo-ciliary synapses that enable rapid signalling to the nucleus are identified in the mouse hippocampus.

    • Katherine Whalley
    Research Highlight
  • Neuromodulation with specific frequencies at specific brain locations selectively enhances either working memory or long-term memory in older adult humans.

    • Jake Rogers
    Research Highlight
  • One major form of timing is the estimation of duration. In this Review, Tsao et al. describe the neural bases for estimating ongoing durations and those for estimating durations between past events within memory.

    • Albert Tsao
    • S. Aryana Yousefzadeh
    • Edvard I. Moser
    Review Article
  • A study in male mice finds that neurons in the bed nucleus of the stria terminalis shape hypothalamic neural representations to control the transition from appetitive to consummatory innate social behaviour towards conspecifics of both sexes.

    • Jake Rogers
    Research Highlight
  • A new study shows that many olfactory sensory neurons in Aedes aegypti mosquitoes express more than one type of chemosensory receptor and some of these neurons can respond to multiple olfactory cues.

    • Darran Yates
    Research Highlight
  • Combining high-throughput fluorescence-activated cell sorting and single-cell RNA sequencing, neurons with and without neurofibrillary tangles from people with Alzheimer disease were shown to have different molecular signatures.

    • Sian Lewis
    Research Highlight
  • Battaglia and colleagues discuss evidence for functional interactions between memory replay and default mode network (DMN) activity and propose an updated model of memory consolidation and retrieval in which the DMN acts as a hub for cascaded replay across the brain.

    • Karola Kaefer
    • Federico Stella
    • Francesco P. Battaglia
    Perspective
  • Dynamin mediates vesicle scission during endocytosis, and here is shown to exist with syndapin 1 in biomolecular condensates at the endocytic zone that enable its participation in ultrafast endocytosis.

    • Sian Lewis
    Research Highlight
  • A study in mice finds that different dopamine neuron subsystems in the midbrain track food and fluid ingestion at different stages of this process, and that animals can use this information to learn about the results of ingestion.

    • Darran Yates
    Research Highlight