Primers and PrimeViews in 2023

This PrimeView highlights the analytical steps involved in molecular QTL mapping to identify associations between variants and molecular phenotypes.

Molecular quantitative trait locus (molQTL) mapping associates genetic variation with molecular traits that can be measured as gene expression, splicing and chromatin accessibility. In this Primer, Aguet et al. discuss the study design and implementation of molQTL mapping in various applications, with a focus on technical developments for functional characterization.

This PrimeView highlights how the diverse properties of covalent organic frameworks can be used for a range of applications

Covalent organic frameworks (COFs) are a class of crystalline porous polymers consisting of highly ordered organic structures formed by polymerization. In this Primer, Tan et al. discuss the design principle, experimental methods, characterization and applications of COFs.