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Volume 18 Issue 12, December 2020

‘Digging up the past’, inspired by the review article on page 717.

Cover design: Philip Patenall.

Feature

  • Scientists around the world have risen to the challenges posed by COVID-19 by rapidly transforming their laboratories and refocusing their research efforts.

    • Ursula Hofer
    • Andrea Du Toit
    • Ashley York

    Series:

    Feature

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Research Highlights

  • Two recent studies use electron cryomicroscopy to determine the architecture of bacterial flagellum stator complexes.

    • Akila Sridhar
    Research Highlight
  • This study discovered that the maternal gut microbiota of mice modulates fetal neurodevelopment during homeostasis and the behaviour of offspring in adult life.

    • Ashley York
    In Brief
  • A recent study suggests that anthropogenic disturbance of grasslands changes the sensitivity of plant pathogens to climate change.

    • Ashley York
    In Brief
  • This study provides insights into how a mycovirus decreases the pathogenicity of its fungal host and promotes plant defences, and how this can be translated into the development of a plant vaccine.

    • Andrea Du Toit
    Research Highlight
  • In this study, the authors have used a modular approach to create synthetic acetylation-resistant streptogramins.

    • M. Teresa Villanueva
    Research Highlight
  • This study reported the discovery of two new relatives of rubella virus, ruhugu virus in bats and rustrela virus in mice.

    • Grant Otto
    In Brief
  • This study found that Pseudomonas aeruginosa biofilms impede the motility of the nematode bacterivore Caenorhabditis elegans.

    • Grant Otto
    In Brief
  • This study provides evidence that bacterial nanotubes produced by Bacillus subtilis and other bacteria are a feature of cell death rather than physiological structures.

    • Grant Otto
    In Brief
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News & Analysis

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Reviews

  • Advances in imaging techniques have revealed an unexpected abundance and diversity of organelles in bacteria. In this Review, Greening and Lithgow outline the different types of bacterial organelles and discuss common themes in their formation and function.

    • Chris Greening
    • Trevor Lithgow
    Review Article
  • The COVID-19 pandemic has prompted unparalleled progress in the development of vaccines and therapeutics in many countries, but it has also highlighted the vulnerability of resource-limited countries in Africa. Margolin and colleagues review global efforts to develop SARS-CoV-2 diagnostics, therapeutics and vaccines, with a focus on the opportunities and challenges in Africa.

    • Emmanuel Margolin
    • Wendy A. Burgers
    • Edward P. Rybicki
    Review Article
  • Viruses are extremely diverse and not all of this diversity has been captured so far. In this Review, Martínez Martínez, Martinez-Hernandez and Martinez-Garcia explore the potential and limitations of single-virus genomics and how this emerging technology can complement other methods.

    • Joaquín Martínez Martínez
    • Francisco Martinez-Hernandez
    • Manuel Martinez-Garcia

    Series:

    Review Article
  • Fungi originated in a freshwater environment and their evolution accompanied the rise of algae and land plants. In this Review, Berbee and colleagues examine the fossil and genomic record of ancient fungi and the inferences we can make about their lifestyle.

    • Mary L. Berbee
    • Christine Strullu-Derrien
    • John W. Taylor
    Review Article
  • Genome-scale models (GEMs) are mathematical representations of reconstructed networks that facilitate computation and prediction of phenotypes, and are useful tools for predicting the biological capabilities of microorganisms. In this Review, Fang, Lloyd and Palsson discuss the development and the emerging application of GEMs.

    • Xin Fang
    • Colton J. Lloyd
    • Bernhard O. Palsson
    Review Article
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