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Two recent studies provide mechanistic understanding of how bacteria employ the Gabija system for defence against phages, as well as how phages use anti-defence proteins to overcome bacterial immunity.
In this study, Lee et al. analyse the structure and receptor-binding features of the spike glycoprotein from a clade 3 sarbecovirus to examine the risk of spillover from bats to humans.
In this study, Simonis et al. show that chronic infection with Pseudomonas aeruginosa leads to development of neutralizing antibodies that could be exploited to fight against this pathogen.
In this study, Wang et al. show that bacterium-derived intestinal ammonia modulates glutamine production in the mouse brain and reduces stress-induced depressive-like behaviour.
This study reports the identification of an archaeal virus Acr protein that blocks the dissociation of the target RNA from the type III-B CRISPR–Cas effector complex, which prevents the recycling of the complex.
In this study, Yan et al. developed a broad-spectrum protein-free vaccine that protects against infection with bacterial and fungal nosocomial pathogens.
This study reports the identification of the novel Candida auris-specific adhesin Scf1, which, together with the adhesin Iff4109, is a key mediator of surface association, infection and long-term colonization.
This study shows that intercellular long extensions promote the evasion of antibody neutralization and the efficient intercellular transmission of chikungunya virus in vitro and in vivo.
In this study, Huang et al. discover Delftia tsuruhatensis TC1, a mosquito symbiotic bacterium that inhibits parasite development via the secretion of a small molecule.
In this study, Sharafutdinov et al. report a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is associated with gastric cancer.
This study shows that Haloferax volcanii uses its type IV pili for cell attachment to a surface and mechanical cohesion between cells under flow conditions, thus promoting biofilm development.