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John Gunn and colleagues summarize recent progress in our understanding of the mechanisms of gall bladder infection bySalmonella enterica subsp. enterica serovar Typhi, in particular the mechanisms involved in S. Typhi biofilm formation on gallstones.
Colicins are folded protein toxins that must translocate across one or both of theEscherichia coli cell membranes to induce cell death. In this Progress article, Colin Kleanthous discusses recent advances in our understanding of the molecular determinants of colicin translocation into E. coliand the novel insights that this has provided into host protein function.
Survival of intracellularPlasmodiumparasites requires that the parasites remodel the host cell through the export of parasite proteins. Goldberg and Cowman describe recent insights into the complex export pathway of parasite proteins, which are transferred from the parasite endoplasmic reticulum into the host cell.
In this Progress article, the authors discuss recent advances in our understanding of the molecular mechanisms used by bacteria to evade complement activation, usingStaphylococcus aureus and Neisseria meningitidisas examples of bacteria that avoid complement using mainly secreted and surface-exposed proteins, respectively.
Danielle Garsin looks at the recent progress that has been made in our understanding of ethanolamine utilization, including the evidence linking ethanolamine utilization to pathogenesis in a diverse range of bacterial pathogens.
DNA replication is an essential process that requires very careful regulation. Tsutomu Katayama and colleagues describe the many ways in which the initiation of chromosomal DNA replication is controlled, with a particular focus on the regulation of DnaA.