Volume 9 Issue 5, May 2008

From The Editors

Research Highlights


  • Review Article |

    Asymmetric cell division, which occurs when a mother cell gives rise to two daughter cells with different fates, is crucial for generating diversity during development and for the function of stem cells. Studies in flies and worms have provided important advances for understanding this process.

    • Pierre Gönczy
  • Review Article |

    Adipose tissue controls whole-body lipid flux, thereby modulating both glucose and lipid homeostasis in humans. Discovery of new targets that regulate fatty acids in adipocytes might lead to therapeutic modalities that can prevent insulin resistance and type 2 diabetes.

    • Adilson Guilherme
    • , Joseph V. Virbasius
    • , Vishwajeet Puri
    •  & Michael P. Czech
  • Review Article |

    Cell death has historically been divided into regulated (apoptotic) and unregulated (necrotic) mechanisms. Emerging evidence, however, suggests that these two categories do not adequately explain all cell death mechanisms. How and why might non-apoptotic, regulated cell death mechanisms have evolved?

    • Alexei Degterev
    •  & Junying Yuan
  • Review Article |

    DNA helicases and translocases have essential roles in nucleic acid metabolism. Processive helicases must translocate along DNA; however, enzyme self assembly and/or interactions with accessory proteins can regulate the separate translocase and helicase activities of some of these enzymes.

    • Timothy M. Lohman
    • , Eric J. Tomko
    •  & Colin G. Wu


  • Analysis |

    The p53 protein regulates the transcription of many target genes in response to a wide variety of stress signals. This Analysis article presents the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.

    • Todd Riley
    • , Eduardo Sontag
    • , Patricia Chen
    •  & Arnold Levine