Volume 7 Issue 9, September 2006

From The Editors

Research Highlights

Reviews

  • Review Article |

    Since their discovery in the late 1980s, SNARE proteins have been recognized as key components of protein complexes that drive intracellular membrane fusion. Despite considerable sequence divergence, their mechanism seems to be conserved and is adaptable for diverse fusion reactions.

    • Reinhard Jahn
    •  & Richard H. Scheller
  • Review Article |

    The anaphase promoting complex/cyclosome (APC/C) is the largest known complex that catalyses ubiquitylation reactions and has key functions in the eukaryotic cell cycle. Recent studies have shed light on how APC/C activity is controlled and how it recognizes a multitude of substrates.

    • Jan-Michael Peters
  • Review Article |

    The recent mapping of histone modifications across the Saccharomyces cerevisiae genome has allowed the analysis of how combinations of modified and unmodified chromatin states relate to each other and particularly to chromosomal landmarks, such as heterochromatin, centromeres, promoters and coding regions.

    • Catherine B. Millar
    •  & Michael Grunstein

    Collection:

  • Review Article |

    The INK4b–ARF–INK4a locus encodes three proteins that are implicated in senescence and tumour suppression. Individual genes are controlled by positive and negative regulators in different contexts, and the entire locus might be suppressed by a cis-acting regulatory domain or by Polycomb-group repressors.

    • Jesús Gil
    •  & Gordon Peters
  • Review Article |

    The Notch pathway functions during diverse developmental and physiological processes. Our current understanding of the mechanisms that function on the core Notch pathway shows that we are still just beginning to understand the full complexities of Notch regulation.

    • Sarah J. Bray

Perspectives

    Innovation

  • Innovation |

    Fluorescence microscopy is a powerful tool to assay biological processes in intact living cells. Now, fluorescence microscopy is becoming a quantitative and high-throughput technology that can be applied to functional genomics experiments and can provide data for systems-biology approaches.

    • Rainer Pepperkok
    •  & Jan Ellenberg
  • Opinion