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Following recent changes around the Twitter platform, Robert Insall highlights the importance of social media in science communication and networking, and ponders on the future of science Twitter.
In this Tools of the Trade article, Patrik Risteski (at Tolić lab) describes high-throughput fluorescent speckle microscopy (FSM) based on a cell-permeable dye that allows to study dynamics of individual microtubules in human cells.
McCarthy et al. identify distinct populations of smooth muscle cells in the intestine that support the establishment of the intestinal stem cell niche during postnatal development by supplying trophic signals to enable niche expansion.
Self-assembly of replication protein A (RPA) into dynamic condensates after binding of single-stranded DNA promotes telomere maintenance in cancer cells.
Discovery of the wide conservation of the homeodomain provided revolutionary insight into gene function and ushered in the birth of evolutionary developmental biology (evo-devo).
The proteins apoptosis regulator BAX (BAX), BCL-2 homologous antagonist/killer (BAK) and BCL-2-related ovarian killer protein (BOK), gasdermins and mixed lineage kinase domain-like protein (MLKL) are key executioners of regulated cell death by forming pores across the plasma or mitochondrial membrane. This Review discusses structural rearrangements during activation and oligomerization of these proteins and highlights commonalities and differences of pore formation mechanisms.
Pools of quiescent adult stem cells support tissue turnover and regeneration in mammals. Recent studies shed new light on the roles of post-transcriptional mechanisms in controlling entry into, maintenance of and exit from the quiescent state, with important implications for regenerative medicine.
Metabolites are generally viewed as intermediates or products of metabolism. However, many metabolites are also signalling molecules that regulate metabolic reactions and other processes in development, homeostasis and disease. As such, metabolites can confer adaptive responses to environmental changes.
